Searchable abstracts of presentations at key conferences in endocrinology

ea0020p347 | Diabetes and Cardiovascular | ECE2009

Association between polymorphisms in the promoter of heme oxygenase-1 and vascular complications in type 2 diabetic patients

Lee Yong-Ho , Kang Eun Seok , Ahn Chul Woo , Cha Bong Soo , Lee Hyun Chul

Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to carbon monoxide, free iron, and biliverdin, which is then changed into bilirubin. These substances have been recently demonstrated to have antiatherogenic and antioxidative properties. The GT-repeat polymorphism is reported to be an independent risk factor for restenosis after coronary stenting and T (−413). A polymorphism increased the activity of HO-1 promoter, leading to reduce the incidence of ischemic heart...

ea0056p296 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Relationship between the triglyceride glucose index and the presence and fibrosis of nonalcoholic fatty liver disease in Korean adults

Kim Min Kyung , Kim Doo Man , Lee Sang Bae , Kang Shinae , Nam Ji Sun , Park Jong Suk , Ahn Chul Woo

Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults.Methods: In total, 51...

ea0063gp28 | Diabetes and Cardiovascular Disease | ECE2019

The synergistic impact of apolipoprotein B/ A-1 and lipoprotein (a) on coronary artery calcification

Ahn Chul Woo , Choi Arim , Kim Jung Hye , Park Kahui , Lee Sang Bae , Kim Yusik , Nam Ji Sun , Kang Shinae , Park Jong Suk

Objective: Apolipoprotein B/Apolipoprotein A-1 ratio (Apo B/Apo A-1) and lipoprotein (a) (Lp(a)) are known to be associated with atherosclerotic vascular disease. We investigated the influence of Apo B/Apo A-1 and Lp(a) on coronary artery calcification (CAC) among healthy Korean adults.Methods: A total of 1081 participants underwent cardiac computed tomography in health promotion center were enrolled. Anthropometric profiles and multiple cardiovascular r...

ea0063gp85 | Thyroid Nodules and Cancer | ECE2019

Follistain-like 1 (Fstl1) may reduce metastastic activity of anaplastic thyroid cancer by increasging thyroid transcription factor 1 (TTF1) and epithelial gene markers

Park Jong Suk , Choi Arim , Kim Jung Hye , Park Kahui , Lee Sang Bae , Kim YuSik , Nam Ji Sun , Kang Shinae , Ahn Chul Woo

Background: Although anaplastic thyroid cancer (ATC) is found in less than 2% of patients with thyroid cancer, it is the most advanced, aggressive and lethal. ATC is known to develop from well-differentiated thyroid cancers, such as follicular thyroid cancer, and it is undifferentiated itself. Among the thyroid-specific transcription factors that are critical for the function of thyroid, the expression of thyroid transcription factor 1 (TTF1), or NKX2.1, has been reported to c...

ea0063p583 | Diabetes, Obesity and Metabolism 2 | ECE2019

Metabolic effects of a novel myokine, Follistatin like protein 1 (FSTL1), in human primary adipocytes

Kim Jung Hye , Choi Arim , Park Kahui , Lee Sang Bae , Kim YuSik , Nam Ji Sun , Kang Shinae , Park Jong Suk , Ahn Chul Woo

Object: FSTL1, an extracellular glycoprotein, is a novel myokine that is secreted by skeletal muscle. However, its functions in metabolism remain unclear, Adipose tissue is one of the important organs for maintaining energy homeostasis. FSTL1 is known to induce inflammatory response and inhibit insulin-mediated Akt signaling pathway, we aimed to investigate whether FSTL1 play metabolic roles in human adipose tissue. We hypothesized that FSTL1 increases lipolysis throu...

ea0049gp54 | Cardiovascular & Lipid Endocrinology | ECE2017

Correlation between triglyceride glucose index (TyG) and coronary artery calcification in Korean adults

You Jihong , Park Kahui , Kim Jung Hye , Lee Sang Bae , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Triglyceride glucose (TyG) index is considered a surrogate marker of insulin resistance, and insulin resistance is known risk factor of cardiovascular disease. Until now, few studies have investigated the relationship between TyG index and coronary artery calcification (CAC), thus we investigated the correlation between TyG index and CAC in healthy Korean Adults.Methods: A total of 4,463 participants underwent cardiac computed tomography in he...

ea0049gp87 | Diabetes & complications 2 | ECE2017

Baicalin lowers glucose intolerance by controlling pancreatic hormone in high fat-induced obese diabetic rats

Park Kahui , Kim Jung Hye , Lee Sang Bae , You Ji Hong , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Bacalin was known as an allosteric modulator of the benzodiazepine sites of the γ-aminobutyric acid A receptor (GABAAR), which produce anxiolytic effects in mice without myorelaxant or sedative effects. Baicalin occur flavonoid found in naturally in the genus Scutellaria. It has been recently shown to exert metabolic effects by attenuating hyperglycemia-induced mitochondrial damage in β-cells in diabetic rats, high-fat diet- (HFD-) indu...

ea0049ep452 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Influence of a part of Korean red ginseng on blood glucose control and complication markers of type 2 diabetic NSY rats

Kim Jung Hye , Park Kahui , Lee Sang Bae , You Ji Hong , Kim Yusik , Park Jong Suk , Nam Ji Sun , Ahn Chul Woo

Objective: Ginsenoside or saponin, is considered as the major bioactive component mediating the therapeutic properties of Korean red ginseng (KRG). However, the exact physiological mechanism underlying anti-diabetic effects is still not fully Clarified. More than 30 different saponins together account for only about 3–4% of KRG, thereby, it is assumed that non-saponin fraction of KRG also carry potential anti-diabetic effects; however, there is no study reporting the diff...

ea0049ep531 | Diabetes complications | ECE2017

Significance of hemorheological approach for screening diabetic nephropathy in the type II diabetes mellitus

Lee Sangbae , Park Kahui , Kim Jung Hye , You Ji Hong , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients and assessed their possible role as a diagnostic tool for diabetic nephropathy.Methods: Four hundred-seventy patients with type 2 diabetes were included in this study. Hemorheologic parameters, including erythrocyte deform...

ea0049ep531 (1) | Diabetes complications | ECE2017

Significance of hemorheological approach for screening diabetic nephropathy in the type II diabetes mellitus

Lee Sangbae , Park Kahui , Kim Jung Hye , You Ji Hong , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients and assessed their possible role as a diagnostic tool for diabetic nephropathy.Methods: Four hundred-seventy patients with type 2 diabetes were included in this study. Hemorheologic parameters, including erythrocyte deform...